News & Events
December 15, 2014
NEW STEM CELL STATE: THE “F-CLASS” CELL

Through cellular reprogramming, researchers have produced a novel pluripotent mouse stem cell in vitro

Researchers from Mount Sinai Hospital’s Lunenfeld-Tanenbaum Research Institute and their international colleagues have uncovered a new type of pluripotent mouse stem cell—the “F-class” cell—through use of a somatic cell reprogramming approach. An F-class cell is able to differentiate into all three embryonic precursor tissues, yet is phenotypically and molecularly different from previously characterized induced pluripotent stem cells (iPSCs) made from somatic cells. These F-class cells proliferate more quickly than other stem cells in vitro, and are characteristically low-adhesion, giving them a fuzzy appearance. The results were published last week in Nature.

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