EDITED BY: Marta Magariños, Marta Milo and Isabel Varela-Nieto
PUBLISHED IN: Frontiers in Aging Neuroscience
Marta Magariños, Instituto de Investigaciones Biomédicas “Alberto Sols”, CSIC-UAM, Spain; CIBERER, Unit 761, Instituto de Salud Carlos III, Spain; Universidad Autónoma de Madrid, Spain
Marta Milo, University of Sheffield, UK
Isabel Varela-Nieto, Instituto de Investigaciones Biomédicas “Alberto Sols”, CSIC-UAM, Spain; CIBERER, Unit 761, Instituto de Salud Carlos III, Spain; IdiPAZ, Instituto de Investigación Sanitaria, Spain
Worldwide, 278 million people are estimated to have moderate to profound hearing loss. Age related hearing loss, also known as presbyacusis, affects approximately half of the population over 60 years old, making it the second most common cause of disability in older people. Hearing loss occurs when the sensory cells and neurons of the cochlea degenerate and die. The vestibular system, which holds the sense of balance, shares a common embryonic origin with the cochlea and together conform the inner ear. Balance problems are a trait of ageing to the point that balance ability is considered a sensor of physical decline and vestibular degeneration is the most common cause of falls in the elderly. Still the molecular bases of ageing in the vestibular system have not been studied in detail. Genetic and environmental factors contribute to the progression of age-related hearing loss (ARHL). Being noise the main environmental noxious agent for human hearing in the industrialized societies.
There is no restorative treatment for deafness but functional replacement by means of prosthesis. Therefore, prevention and treatment of hearing loss is an unmet medical need. To develop innovative medical strategies against hearing loss, it is critical to understand the causes of ARHL and the essential pathways responsible for the manifestation of this complex disease.
In this research topic, experts will discuss the stages and molecular elements of the damage and repair processes involved in ARHL, from cellular processes to molecules involved in aging.
Oxidative stress takes a central stage as an essential element in the progression of injury and cell loss, and a target for cell protection strategies. Finally, the mechanisms of action and the potential of novel therapies for hair cell repair and protection will be discussed along with drug delivery strategies.
Citation: Magariños, M., Milo, M., Varela-Nieto, I., eds. (2015). Aging, Neurogenesis
and Neuroinflammation in Hearing Loss and Protection. Lausanne: Frontiers Media.